The Nephroprotective Effect of Zizphus Jujuba Extract Against 5-Flurouracil- Induced Nephropathy

This study assessed the protective effect of Zizphus jujube (ZJ) extract on 5‑FU‑induced alterations in renal function markers and kidney morphology Dawley rats. Twenty-four rats were divided randomly into four groups administrated orally with 0.9% normal saline as control group, 5-FU (40 mg/kg daily for 5 days), ZJ (500 mg/ kg 5-FU+ (for 6 days). further biochemical experiments carried out blood collected from heart. Kidney tissues obtained analysis catalase (Cat), glutathione S-transfers (GST), lipid peroxide levels well histology analysis. significantly reduced enzyme activity Cat GST increased peroxidation plasma creatinine (P < 0.005). Histopathological examination showed severe wide ischemia proximal convoluted tubule (PCT), missing Bowman's space, edema group treated 5-FU. In addition, pretreatment has improved 0.05). Moreover, histopathological that relatively prevented damage tubular cells compared group. Supplementation may have clinical benefit nephrotoxicity caused by 5‑FU.